RESEARCH ARTICLES
Influence of age on the pathology of hippocampus and variation in the number of neurons of the hilar region in the brain of dogs
T. Dhanya, K. S. Prasanna, P. Hamza, R. Anoopraj, M. Pradeep, V. Elizabeth, M. T. K. Alin and J. G. Ajith
doi: : https://doi.org/10.51966/jvas.2022.53.3.380-384
Journal of Veterinary and Animal Sciences.2022.53(3):380-384.
Author Details
T. Dhanya: MVSc Scholar, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Pookode, Wayanad – 673 576 Kerala Veterinary and Animal Sciences University, Kerala, India
K. S. Prasanna: Assistant Professor, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Pookode, Wayanad – 673 576 Kerala Veterinary and Animal Sciences University, Kerala, India
P. Hamza: Assistant Professor, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Pookode, Wayanad – 673 576 Kerala Veterinary and Animal Sciences University, Kerala, India
R. Anoopraj: Assistant Professor, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Pookode, Wayanad – 673 576 Kerala Veterinary and Animal Sciences University, Kerala, India
M. Pradeep: Assistant Professor, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Pookode, Wayanad – 673 576 Kerala Veterinary and Animal Sciences University, Kerala, India
V. Elizabeth: MVSc Scholar, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Pookode, Wayanad – 673 576 Kerala Veterinary and Animal Sciences University, Kerala, India
M. T. K. Alin: MVSc Scholar, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Pookode, Wayanad – 673 576 Kerala Veterinary and Animal Sciences University, Kerala, India
J. G. Ajith: Professor and Head, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Pookode, Wayanad – 673 576 Kerala Veterinary and Animal Sciences University, Kerala, India
Article History
Received: 31.01.2022, Accepted: 19.03.2022, Published online: 30.09.2022
Corresponding author: K. S. Prasanna
e-mail: prasanna@kvasu.ac.in
Citation: Dhanya, T., Prasanna, K. S., Hamza, P., Anoopraj, R., Pradeep, M., Elizabeth. V., Alin, M. T. K and Ajith, J. G. 2022. Influence of age on the pathology of hippocampus and variation in the number of neurons of the hilar region in the brain of dogs. J. Vet. Anim. Sci. 53(3): 380-384
DOI: https://doi.org/10.51966/jvas.2022.53.3.380-384
Abstract
Brain is a vital organ that always has high oxygen demands and is highly vulnerable to injury caused by reactive oxygen species (ROS). The hippocampus is a complex structure seen deep in the temporal lobe which is constituted by the dentate gyrus, hippocampus proper (Cornu Ammonis- CA1-CA4) and subiculum. The important functions of the hippocampus are learning and memory. Age-influenced pathological lesions in the hippocampus and variation in the number of neurons in the hilus are the main discussion of this study. The major gross lesions observed in the brain of both younger and older dogs were cerebral congestion, thickened meninges and cerebral edema. The major histopathological findings in the hippocampus were thickened blood vessels, accumulation of lipofuscin pigments in the neuronal cytoplasm, satellitosis, gliosis, neurons with the vesicular nucleus, chromatolysis and neuronophagia. A statistically significant reduction in the number of neurons in the hilar region of the hippocampus was observed in aged dogs.
Keywords: Dog, hippocampus, age, neuron loss, hilus
