RESEARCH ARTICLES
Desmoplastic reactions associated with malignant canine mammary tumours
S. S. Devi, A. J. George, B. Dhanush Krishna, K. S. Prasanna, G. Radhika and K. D. John Martin
doi: https://doi.org/10.51966/jvas.2022.53.4.694-698
Journal of Veterinary and Animal Sciences.2022.53(4):694-698.
Author Details
S. S. Devi : Assistant Professor , Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651, Kerala Veterinary and Animal Sciences University, Kerala, India.
A. J. George : Professor and Head, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Kerala, India.
B. Dhanushkrishna : Assistant Professor , Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651, Kerala Veterinary and Animal Sciences University, Kerala, India.
K. S. Prasanna : Assistant Professor , Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651, Kerala Veterinary and Animal Sciences University, Kerala, India.
G. Radhika : Professor, Department of Animal Genetics and Breeding, College of Veterinary and Animal Sciences,Mannuthy, Thrissur- 680 651, Kerala Veterinary and Animal Sciences University, Kerala, India.
K.D. John Martin : Professor and Head, Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651, Kerala Veterinary and Animal Sciences University, Kerala, India.
Article History
Received: 28.06.2022, Accepted: 03.09.2022, Published online: 31.12.2022
Corresponding author: S. S. Devi
e-mail : deviss@kvasu.ac.in
Citation: Devi, S.S., George A.J., Dhanush Krishna, K.B., Prasanna, K.S., Radhika, G. and John Martin, K.D. 2022. Desmoplastic reactions associated with malignant canine mammary tumours. J. Vet. Anim. Sci. 53(4): 694-698
DOI: https://doi.org/10.51966/jvas.2022.53.4.694-698
Abstract
Desmoplastic reactions or desmoplasia, characterised by proliferation of fibrotic connective tissue around tumour cells, have been described as a prognostic indicator of malignancy in human breast cancers. Desmoplasia ultimately results in deposition of collagen that shows significant differences in its density and orientation at different stages of tumourigenesis. The different collagen patterns associated with tumours are referred to as tumour associated collagen signatures (TACS) and are identified as hallmarks in human tumourigenesis. The present study was aimed to demonstrate the presence of TACS in canine mammary tumours (CMTs). The desmoplastic reactions and collagen deposition occurring in association with CMTs were analysed using routine histopathological, special staining and scanning electron microscopy techniques. Thirty excisional biopsy samples collected from malignant CMTs were utilised for studying the progression of desmoplastic reactions occurring in the tumour associated stroma.
Key words: Canine mammary tumours, Desmoplasia, scanning electron microscopy, tumour associated collagen signatures
