RESEARCH ARTICLES

Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis
M. R. Krishna Nath, N. Madhavan Unny, Sindhu K. Rajan, Usha Narayana Pillai and V. Ramnath

doi: https://doi.org/10.51966/jvas.2023.54.1.86-90

Journal of Veterinary and Animal Sciences.2023.54(1):86-90

Author Details

M. R. Krishna Nath: MVSc. scholar, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, India.

N. Madhavan Unny: Professor, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, India.

Sindhu K. Rajan : Assistant Professor, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, India.

Usha Narayana Pillai:  Professor and head, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, India.

V. Ramnath. : Professor and head, Department of Veterinary Physiology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur-680651, Kerala Veterinary and Animal Sciences University, Pookode, Kerala, India.

Article History

Received: 12.09.2022 Accepted: 27.12.2022 Published online: 31.03.2023

Corresponding author:M. R. Krishna Nath

e-mail : krishnareghunath27@gmail.com

Citation : Krishna Nath,M.R., Madhavan Unny,N., Sindhu,K.R., Usha,N.P. and Ramnath,V. 2023. Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis. J. Vet. Anim. Sci. 54(1):86-90

DOI: https://doi.org/10.51966/jvas.2023.54.1.86-90



Abstract


The present study was conducted to evaluate the alterations in oxidative stress parameters in dogs suffering from haemorrhagic gastroenteritis (HGE). Dogs presented with vomiting and diarrhoea were screened and fifteen animals with signs suggestive of HGE were included in the study. The oxidative stress parameters, serummalondialdehyde (MDA) level, total antioxidant status (TAS) and plasma glutathione peroxidase (GSH-Px) activity were studied. The values were compared with the values from six apparently healthy dogs. A significant increase was noticed in the mean values of serum MDA and TAS of diseased animals at the time of presentation when compared to healthy animals whereas the activity of plasma GSH-Px was found to be lower than in healthy dogs. Supplementation with N-acetyl cysteine @ 70 mg/kg or five days was found effective in managing the oxidative injury in the affected animals.

Keywords: Haemorrhagic gastroenteritis, oxidative stress, N-acetyl cysteine