RESEARCH ARTICLES

Anti-oxidant effect of N-acetyl cysteine in dogs with chronic kidney disease
Neethu Balakrishnan, N. Madhavan Unny, V. R. Ambily, Usha Narayana Pillai and R. Uma

doi: https://doi.org/10.51966/jvas.2023.54.1.138-143

Journal of Veterinary and Animal Sciences.2023.54(1):138-143

Author Details

Neethu Balakrishnan: MVSc scholar, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, India.

N. Madhavan Unny: Professor, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, India.

V. R. Ambily : Assistant Professor, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, India.

Usha Narayana Pillai: Professor and Head, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, India.

R. Uma : Associate Professor, Department of Veterinary Biochemistry, College of Veterinary and Animal Sciences, Mannuthy, Thrissur-680651, Kerala Veterinary and Animal Sciences University, Pookode, Kerala, India.

Article History

Received: 27.10.2022 Accepted: 20.12.2022 Published online: 31.03.2023

Corresponding author: Neethu Balakrishnan

e-mail : neethubalakrishnan50@gmail.com

Citation : Balakrishnan,N., Madhavan Unny,N., Ambily,V.R., Usha,N.P and Uma,R. 2023. Antioxidant effect of N-acetyl cysteine in dogs with chronic kidney disease. J. Vet. Anim. Sci. 54(1):138-143

DOI: https://doi.org/10.51966/jvas.2023.54.1.138-143



Abstract


The present study was carried out with the objectives of assessing oxidative stress in dogs with chronic kidney disease (CKD) and evaluating response to treatment with N-acetyl cysteine (NAC). Dogs diagnosed with stage III CKD as per the guidelines of the International Renal Interest Society (IRIS) were included in the study. The animals were divided into two groups. Animals of one group were given standard therapy for CKD and the animals of the second group were administered NAC along with standard therapy. Oxidative stress parameters such as total antioxidant status (TAS), serum malondialdehyde (MDA) level and plasma glutathione peroxidase (GSH-Px) activity were studied. On the day of presentation, a significant increase in the mean values of serum MDA and TAS were observed in diseased animals compared to healthy animals, whereas a significant decline was noted in plasma GSH-Px activity. After treatment, a significant decline in serum MDA and TAS were recorded in animals of group II receiving NAC therapy. A significant increase in plasma glutathione GSH-Px activity was recorded in this group. N-acetyl cysteine therapy was found to be effective in the management of oxidative stress in dogs with chronic kidney disease.

Keywords: Chronic kidney disease, N-acetyl cysteine, oxidative stress