14. Effect of coenzyme q10 supplementation on total antioxidant status and lipid peroxides levels in dogs with chronic valvular heart disease
K. Revathi, N. Madhavan Unny, Usha Narayana Pillai, R. Uma and S. Ajithkumar
Oxidative stress management has been found to have beneficial effects in the management of several disease conditions. A study was conducted to evaluate the efficacy of Coenzyme Q10 supplementation on the total antioxidant status and lipid peroxides levels in dogs with chronic valvular heart disease. Total antioxidant status was measured by Ferric Reducing Antioxidant Power assay and level of lipid peroxides in serum was determined by estimating malonaldialdehyde level. Ten dogs with chronic chronic valvular heart disease were administered with coenzyme Q10 @ 45mg q12h orally for 60 days along with the treatment for management of valvular heart disease. A significant decline in Ferric Reducing Antioxidant Power value was recorded at the end of the study. The malonaldialdehyde levels declined in animals with chronic valvular heart disease by day 60, though reduction was not statistically significant. The administration of Coenzyme Q10 in chronic valvular heart disease may be beneficial in improving the quality of life of the patient.
Keywords: Dog, Coenzyme Q10, Chronic valvular heart disease, Oxidative stress