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Myoglobinuric acute renal failure in a dog
P P Kanaran, N P Usha, V R Ambily and P C Alex

Department of Clinical Medicine College of Veterinary and Animal Sciences Mannuthy-680651 Thrissur, Kerala, India 

Journal of Veterinary and Animal Sciences.2013. 44:83-84.

Open Access

Copyright: © 2013 Kanaran et.al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

 



Abstract


Rhabdomyolysis is an uncommon disease process with profound sequelae if it is not identified and treated expediently. Clinical presentation varies, ranging from a nearby asymptomatic illness to fulminate and life threatening disease process with multiorgan system failure. Rhabdomyolysis results in the release of myoglobin, a haem pigment, which through multiple effects can result in nephrotoxicity and ARF (Zagar, 1989 and Better and Steain, 1990). The main mechanism is likely to be intra-luminal obstruction by haem pigment casts and ischemia ( Luscher, 1991) and a direct or iron –mediated proximal tubular injury. Treatment should be directed at reducing the nephro-toxic potential of the released pigments which can be achieved by rehydration, correction of acidosis, maintaining good urine output and establishing a urinary pH of 7.0 by forced alkaline diuresis 

Keywords:- Myoglobinurea, Acute Renal Failure