RESEARCH ARTICLES
Comparative efficacy of different treatment regimens against bovine mastitis caused by Staphylococcus aureus
Krupa Rose Jose, K. Vijayakumar, K. Justin Davis, V. H. Shyma, and R. Ambily
doi: https://doi.org/10.51966/jvas.
Author DetailsJournal of Veterinary and Animal Sciences.2021. 52(1):55-59.
Krupa Rose Jose: MVSc. Scholar, Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences, Mannuthy, Kerala Veterinary and Animal Sciences University, Kerala, India.
K. Vijayakumar: Professor and Head, Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences, Mannuthy, Kerala Veterinary and Animal Sciences University, Kerala, India.
K. Justin Davis: Assistant Professor, Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences, Mannuthy, Kerala Veterinary and Animal Sciences University, Kerala, India.
V. H. Shyma: Assistant Professor, Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences, Mannuthy, Kerala Veterinary and Animal Sciences University, Kerala, India.
R. Ambily: Associate Professor, Department of Veterinary Microbiology, College of Veterinary and Animal Sciences, Mannuthy, Kerala Veterinary and Animal Sciences University, Kerala, India.
Article History
Received: 24.11.2020, Accepted: 10.12.2020, Published online: 01.01.2021
Corrersponding author: Krupa Rose Jose
e-mail: krupaputhuparampil@gmail.com
Citation: Jose, K. R., Vijayakumar, K., Justin, D. K., Shyma, V. H. and Ambily, R. 2021. Comparative efficacy of different treatment regimens against bovine mastitis caused by Staphylococcus aureus. J. Vet. Anim. Sci. 52(1) : 55-59.
Abstract
Bovine mastitis is an endemic disease among dairy cattle all over the world and antimicrobial therapy is one of the prime therapeutic and prophylactic tool against mastitis. In the present scenario, the efficacy of antimicrobial chemotherapy is being threatened by the rising tide of antimicrobial resistance. A study was conducted to evaluate the comparative clinico-therapeutic efficacy of three selected antimicrobial protocols among 21 animals with clinical mastitis, from which S. aureus could be isolated. Therapeutic trials were conducted with Inj. Ceftriaxone (10 mg/kg body weight BID) for five days in group I, Inj. Ceftriaxone-sulbactam (6 mg/kg IV BID for five days) in group II and Inj. Sulphadiazine-trimethoprim (15 mg/kg IV BID for five days) in group III. The bacteriological cure was assessed by streaking the milk samples collected 24 h after termination of the treatment on to a bacteriological medium and the clinical cure was assessed by the return to normal colour and consistency of milk and remission of the pathological manifestations in udder. All the treatment groups had exhibited an excellent bacteriological cure rate as evident from the 100 per cent post treatment culture negative samples. The group I exhibited 100 per cent clinical cure whereas, in group II and group II, the clinical cure was 87.5 per cent and 75 per cent respectively. Statistical analysis using Fisher’s exact test revealed that there is no significant difference among the three treatment groups and all the treatment regimens are equally effective.
Keywords: Mastitis, ceftriaxone, ceftriaxone sulbactam, sulphadiazine trimethoprim, clinicotherapeutic efficacy
