Volume: 57 Issue: 1
Year: 2026, Page: 208-216, Doi: https://doi.org/10.51966/jvas.2026.57.1.208-216
Received: March 4, 2026 Accepted: March 17, 2026 Published: March 31, 2026
Diabetic dyslipidaemia is a major contributor to cardiovascular risk in insulin-deficient states. This study evaluated the hypolipidemic activity of an aqueous extract of Tremella fuciformis (AETF) in streptozotocin (STZ)-induced diabetic mice. Male BALB/c mice were rendered diabetic by a single intraperitoneal injection of STZ at a dose of 60 mg/kg body weight. Hyperglycaemic animals exhibiting fasting blood glucose levels ≥250 mg/dL were selected and administered AETF orally at doses of 50 and 100 mg/kg body weight per day for 28 consecutive days. Serum lipid parameters were quantified using enzymatic colourimetric assays. The STZ administration induced significant dyslipidaemia, characterised by elevated triglycerides, total cholesterol, LDL-C, and VLDL-C, along with reduced HDL-C, compared with normal controls (p < 0.0001). AETF administration significantly improved all lipid parameters in a dose-dependent manner, with the 100 mg/kg dose demonstrating greater reductions in atherogenic lipoproteins and restoration of HDL-C relative to diabetic controls. These findings indicate that AETF effectively ameliorates diabetes-associated dyslipidaemia and restores lipoprotein balance, supporting its potential as a functional adjunct for mitigating cardiometabolic risk associated with diabetes.
Keywords: Tremella fuciformis, diabetic dyslipidaemia, streptozotocin, serum lipid profile, hypolipidemic activity
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Wani, Z.A., Sharma, A.K, Muzamil, M. & Yaqoob lone (2026). Amelioration of diabetic dyslipidaemia by an aqueous extract of Tremella fuciformis in streptozotocin-induced diabetic mice. Journal of Veterinary and Animal Sciences, 57(1), 208-216 https://doi.org/10.51966/jvas.2026.57.1.208-216