Journal of Veterinary and Animal Sciences

Volume: 54 Issue: 4

  • Open Access
  • Research Article

Assessment of acute kidney injury in dogs suffering from babesiosis and leptospirosis#

Asma Idrees1, P.M. Deepa2, K. Vinodkumar3, R. L. Rathish3 and M. Pradeep4

# Part of M. V. Sc. thesis submitted to Kerala Veterinary and Animal Sciences University, Pookode, Wayanad, Kerala, India


1 M. V. Sc. Scholar
2 Associate Professor & Head
3 Assistant Professor
4 Assistant Professor, Department of Veterinary Pathology


*Corresponding author: [email protected], Ph. 9895985902

Year: 2023, Page: 921-926, Doi: https://doi.org/10.51966/jvas.2023.54.4.921-926

Received: Dec. 20, 2022 Accepted: Jan. 25, 2023 Published: Dec. 31, 2023

Abstract

Acute kidney injury (AKI) is a serious complication of infectious diseases like babesiosis and leptospirosis in dogs. Both the diseases show similar clinical manifestations, due to which timely differential diagnosis often gets delayed. The present study focused on diagnosis of major infectious agents causing AKI and its grading in dogs. Peripheral blood smear examination and PCR were used for the diagnosis of babesiosis. Leptospirosis was screened using PCR and MAT and was later confirmed by MAT on paired sera sample. Diagnosis of AKI was made based on the increase in serum creatinine levels ≥0.3 mg/dL within 48 h of presentation. Staging of animals was carried out as per International Renal Interest Society (IRIS) guidelines. All the dogs with confirmed leptospirosis and 15 per cent of dogs with babesiosis were diagnosed with AKI. The timely diagnosis of AKI in dogs during their initial stages helps to regain normal renal function within short-term treatment itself.

Keywords: Acute kidney injury, babesiosis, leptospirosis, MAT

References

Cheema, P. S., Srivastava, S. K., Chaudhuri, P., Amutha, R., Singh, S., Sankar, M. and Thangapandian, E. 2007. Cloning and sequencing of a 21 kDa outer membrane protein gene of Leptospira interrogans serovar Canicola strain Hond Utrecht IV. Vet. Res. Commun. 31: 521.

Cowgill, L. D., Polzin, D. J., Elliott, J., Nabity, M. B., Segev, G., Grauer, G. F., Brown, S., Langston, C. and van Dongen, A. M. 2016. Is progressive chronic kidney disease a slow acute kidney injury? Vet. Clinic. Small Anim. Pract. 46: 995-1013.

Defauw, P., Schoeman, J. P., Leisewitz, A. L., Goddard, A., Duchateau, L., Aresu, L., Meyer, E. and Daminet, S. 2020. Evaluation of acute kidney injury in dogs with complicated or uncomplicated Babesia rossi infection. Ticks tick-borne. Dis. 11: 101406.

Dias, C. S., Paz, L. N., Solcà, M. S., Portela, R.W.D., Bittencourt, M. V. and Pinna, M. H. 2021. Kidney Injury Molecule-1 in the detection of early kidney injury in dogs with leptospirosis. Comp. Immunol. Microbiol. Infect. Dis. 76: 101637.

Divya, D., Siju Joseph., Mini, M., Sreeja Nair, R. and Justin Davis, K. 2021. Multilocus sequence typing for species/ serovar identification of clinical isolates of Leptospira. J. Vet. Anim. Sci. 52: 238- 244.

Faine, S. 1982. Guidelines for the control of leptospirosis. 67:171.

Foldvari, G., Hell, E. and Farkas, R., 2005. Babesia canis canis in dogs from Hungary: detection by PCR and sequencing. Vet. Parasitol.127: 221- 226.

Inokuma, H., Yoshizaki, Y., Matsumoto, K., Okuda, M., Onishi, T., Nakagome, K., Kosugi, R. and Hirakawa, M., 2004. Molecular survey of Babesia infection in dogs in Okinawa, Japan. Vet. Parasitol. 121: 341-346.

Komal, S., Jain, T. and Singh, M. 2020. Chronic renal failure in dogs: A case report. J. Entomol. Zool. Stud. 8: 470-471

Kules, J., Bilic, P., Ljubic, B. B., Gotic, J., Crnogaj, M., Brkljacic, M. and Mrljak, V. 2018. Glomerular and tubular kidney damage markers in canine babesiosis caused by Babesia canis. Ticks tickborne. Dis. 9: 1508-1517.

Mannucci, T., Lippi, I., Rota, A. and Citi, S. 2019. Contrast enhancement ultrasound of renal perfusion in dogs with acute kidney injury. J. Small Anim. Pract. 60: 471-476.

Polzin, D. J. 2011. Chronic kidney disease in small animals. Vet. Clin. Small Anim. Pract. 41:15-30.

Rohini, B. G., George, A., Usha, N. P.,MadhavanUnny, N., Ambily, R. and Gleeja, V.L. 2022. A retrospective study of acute kidney injury in dogs with renal resistive index as a prognostic indicator. J. Vet. Anim. Sci. 53: 583-591

Ross, L. 2011. Acute kidney injury in dogs and cats. Vet. Clin. Small Anim. Pract. 41: 1-14. Ross, L. 2022. Acute kidney Injury in dogs and cats. Vet. Clin. Small Anim. Pract. 52: 659-672.

Segev, G., Kass, P. H., Francey, T. and Cowgill, L. D. 2008. A novel clinical scoring system for outcome prediction in dogs with acute kidney injury managed by hemodialysis. J. Vet. Intern. Med. 22: 301-308.

Yang, C. W. 2018. Leptospirosis renal disease: emerging culprit of chronic kidney disease unknown etiology. Nephron. 138:129-136.

Cite this article

Idrees A., Deepa P.M., Vinodkumar K., Rathish R.L. and Pradeep M. 2023. Assessment of acute kidney injury in dogs suffering from babesiosis and leptospirosis. J. Vet. Anim. Sci. 54(4):921-926

Views
84
Downloads
39
Citations