Volume: 54 Issue: 1
Year: 2023, Page: 71-78, Doi: https://doi.org/10.51966/jvas.2023.54.1.71-78
Received: Aug. 4, 2022 Accepted: Oct. 25, 2022 Published: March 31, 2023
A total of 110 dogs presented to Teaching Veterinary Clinical Complex, CSKHPKV, Palampur (H.P.), India with the history of enteritis/gastroenteritis were screened for Canine Parvovirus (CPV). Out of these 110 dogs, 48 dogs were found positive for CPV by using Scanvet - a rapid antigen detection kit. All the 110 samples were subjected to Polymerase Chain Reaction (PCR) to check whether there were some cases that were false positive or false negative by Scanvet. Positive cases were, then, divided into 4 groups of 12 dogs each, with 4 different treatment regimens followed for each group. In addition to standard treatment protocol, our study tested effect of immunomodulators (Vitamin E & Selenium) and antiviral “Oseltamivir” on recovery of dogs. This type of study (using Oseltamivir and immunomodulators) was not done previously in the state and hence, our aim was to test whether this treatment increases survivability and recovery rate for dogs with Parvoviral enteritis in Himachal Pradesh. Groups containing immunomodulators were more efficacious than their counterparts without immunomodulators. Addition of Oseltamivir and immunomodulators to standard therapy resulted in reduced mortality, cessation of diarrhoea and vomiting earlier than routine therapy. Scanvet diagnostic kit was found to be a quick alternate method for diagnosis of Parvo Viral Enteritis. Overall, the group treated with antibiotic+ supportive+ symptomatic+ antiviral treatment along with immunomodulator displayed promising results.
Keywords: Dogs, parvo-virus, severe disease, treatment, diagnostic methods, antiviral
Battilani, M., Bassani, M., Forti, D. and Morganti, L. 2006. Analysis of evolution of Feline Parvo Virus. Vet. Res. Commun. 30: 223–226.
Bhat, A.A., Wadhwa, D.R., Singh, S.P. and Singh, I. 2013. Haematological and biochemical analysis in canine enteritis. Vet World, 6:380-383.
Buonavoglia, C., Martella, V., Pratelli, A., Tempesta, M., Cavalli, A., Buonavoglia, D., Bozzo, G., Elia, G., Decaro, N. and Carmichael, L. 2001. Evidence for evolution of canine parvovirus type 2 in Italy. J. Gen. Virol. 82(12): 3021–3025.
Carmichael, L.E.2005. An annotated historical account of canine parvovirus. J. Vet. Med. B. 52(7-8):303–311.
Chakrabarti, A. 2012. Canine Parvo Viral Enteritis. In: Textbook of Clinical Veterinary Medicine, Oscar publication, Delhi, India.
Decaro, N., Martella, V., Desario, C., Bellacicco, A.L., Camero, M., Manna, L., d'Aloja, D. and Buonavoglia, C. 2006. First detection of canine parvovirus type 2c in pups with haemorrhagic enteritis in Spain. J. Vet. Med. B. 53(10): 468–472.
Decaro, N. and Buonavoglia, C. 2012. Canine parvovirus: A review of epidemiological and diagnostic aspects, with emphasis on type 2c. Vet. Microbiol. 155(1):1–12.
de Mari, K., Maynard, L., Eun, H.M. and Lebreux, B. 2003. Treatment of canine parvoviral enteritis with interferon-omega in a placebo-controlled field trial. Vet Rec. 152:105-108.
Goddard, A. and Leisewitz, A.L. 2010. Canine Parvovirus. Vet. Clin. North Am. Small Anim. Pract. 40:1041-1053.
Greene, C.E. 2012. Feline enteric viral infections. In: Greene CE, editor. Infectious Diseases of the Dog and Cat. (4thEd.) St Louis, MO-Elsevier Saunders: 80–91.
Gubareva, L.V., Kaiser, L. and & Hayden, F.G. 2000. Influenza virus neuraminidase inhibitors. Lancet. 335:827-835.
Kalli, I., Leontides, L.S., Mylonakis, M.E., Adamama-Moraitou, K., Rallis, T. and Koutinas, A.F. 2010. Factors affecting the occurrence, duration of hospitalization and final outcome in canine parvovirus infection. Res. Vet. Sci. 89(2): 174–178.DOI: 10.1016/j.rvsc.2010.02.013.
Kandil, O.M and Zeina, H.A. 2005. Effect of Parenteral Vitamin E and Se supplementation on immune status of dogs vaccinated with subunit and somatic antigens against Taenia hydatigena. J. Egypt Soc. Parasitol. 35(2):537-50.
Markovich, J.E., Stucker, K.M., Carr, A.H., Harbison, C.E., Scarlett, J.M. and Parrish, C.R. 2012. Effects of canine parvovirus strain variations on diagnostic test results and clinical management of enteritis in dogs. J. Am. Vet. Med. Assoc. 241(1):66–72. DOI: 10.2460/javma.241.1.66.
Martella, V., Decaro, N. and Buonavoglia, C. 2006. Evolution of CPV-2 and implication for antigenic/genetic characterization. Virus Genes. 33(1):11–13.
Mosallanejad, B., Ghorbanpoor, N.M., Avizeh, R. and Ronagh, A. 2008. Prevalence of Canine Parvo Virus infection in diarrheic dogs referred to veterinary hospital in Ahvaz. Arch. Razi Inst. 63(2):41-46.
Navya, E., Vinodkumar, K., Justin Davis, K., Priya P.M., Ashmy, K. and Vijayakumar K. 2022. Prognostication of haemato-biochemical, electrolyte and blood gas parameters in canine parvoviral enteritis. J. Vet. Anim. Sci. 53(3): 333-339. https://doi.org/10.51966/jvas.2022.53.3.333-339.
Ntafis, V., Xylouri, E., Kalli, I., Desario, C., Mari, V., Decaro, N. and Buonavoglia, C. 2010. Characterization of canine parvovirus type 2 (CPV-2) variants circulating in Greece. J. Vet. Diagn. Invest. 22(5): 737–740. DOI-10.1177/104063871002200512.
Oh, J.S., Ha. G.W., Cho, Y.S., Kim, M.J., An, D.J., Hwang, K.K., Lim, Y.K., Park, B.K., Kang, B. and Song, D.S.2006. One-step immunochromatography assay kit for detecting antibodies to canine parvo virus. Clin. Vaccine Immunol. 13(4): 520-524.
Pereira, C.A., Monezi, T.A., Mehnert, D.U., Angelo,M. D'. and Durigon, E. L. 2000.Molecular characterization of Canine Parvo Virus in Brazil by PCR. Vet. Microbiol. 75(2):127-133.
Prittie, J. 2004. Canine parvo viral enteritis: A review of diagnosis, management and prevention. J. Vet. EmergCrit Care 14:167-176.
Reddy K, Basava., Shobhamani, B., Sreedevi, B. and Prameela, D. Rani. 2015. Diagnosis of Canine Parvo Viral (CPV) Infection in Dogs. IntasPolivet 16(2):441-442.
Roy, S., Roy, M. and Sagar, K.A. 2010. Haemato-biochemical and therapeutic studies of canine parvo viral infection. IntasPolivet 11:344-347.
Savigny, M.R. and Macintire, D.K.2010 Use of Oseltamivir in the treatment of canine parvoviral enteritis. J. Vet. EmergCrit Care 20:132-142.
Schatzberg, S.J., Haley, N.J., Barr, S.C., Parrish, C., Steingold, S., Summers, B.A., deLahunta, A., Kornegay, J.N. and Sharp, N.J.H. 2003. Polymerase Chain Reaction Amplification of Parvoviral DNA from the brains of dogs and cats. J. Vet. Intern. Med.17(4): 538-544.DOI: 10.1111/j.1939-1676.2003.tb02475.x.
Sykes, J.E. 2013. Canine parvovirus infections and other viral enteritides. In: Sykes JE, editor-Canine and Feline Infectious Diseases, (1stEd.), St Louis, MO: Elsevier: 141-151.
Tinky, S.S., Ambily, R., Nair, S.R. and Mini, M. 2015. Utility of a rapid immunochromatographic strip test in detecting canine parvovirus infection compared with polymerase chain reaction. Vet. World 8(4):523-526.
Truyen, U. 2006. Evolution of canine parvovirus-a need for new vaccines? Vet. Microbiol. 117(1):9-13.
© 2023 Shruti and Ajay. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Shruti,G. and Ajay,K. 2023. Canine parvo viral enteritis in dogs: Diagnostic and therapeutic evaluation. J. Vet. Anim. Sci. 54(1):71-78
DOI: https://doi.org/10.51966/jvas.2023.54.1.71-78