Volume: 56 Issue: 2
Year: 2025, Page: 332-337, Doi: https://doi.org/10.51966/jvas.2025.56.2.332-337
Received: Feb. 20, 2025 Accepted: March 21, 2025 Published: June 30, 2025
Biomaterial implants for soft tissue repairs often lack biomechanical properties, leading to deformation and failure in integration and regeneration. Extracellular matrix-based collagen implants are potential candidates, but their mechanical properties vary by extraction method and source. Cross-linking, a common process, is used to modify these properties. Hence, the present study aims to investigate the biomechanical properties of chemically and enzymatically decellularised porcine tunica vaginalis scaffolds (DPTV) and glutaraldehyde cross-linked decellularised porcine tunica vaginalis scaffolds (DGPTV). Biomechanical properties of Ultimate tensile strength, Young’s modulus, elongation at break, and strain at maximum load were estimated. The materials did not differ in tensile strength. However, a significant increase in Young’s modulus was observed in DPTV implants. A significant increase in elongation at break and strain at maximum load was observed in DGPTV implants. This increase in biomechanical properties of cross-linked materials is attributed to the formation of new bonds between the collagen bundles, and the increase in fibre crimp of collagen fibres. These properties could translate to better flexibility of cross-linked materials while retaining sufficient tensile strength to support surgical implantation.
Keywords: Biomaterials, scaffolds, biomechanical properties, glutaraldehyde cross-linking, porcine tunica vaginalis
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© 2025 Abin et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0
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J. Vet. Anim. Sci. 56 (2):332-337