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Journal of Veterinary and Animal Sciences

Volume: 55 Issue: 4

  • Open Access
  • Short Communication

Effect of age on anti-rabies immune response in pet dogs of Thrissur district, Kerala, India: a cross-sectional study

V. Vani1*, Sreeja R. Nair2, E. Sreekumar3, P. M. Priya1, Binu K. Mani1 and K. Justin Davis4

1Department of Veterinary Microbiology, College of Veterinary and Animal Sciences, Thrissur- 680 651, 2Bioscience
Research and Training Centre, Thiruvananthapuram- 695 317, Kerala Veterinary and Animal Sciences University,
Wayanad, Kerala India, 3Institute of Advanced Virology, Thiruvananthapuram- 695 317, Kerala, India, 4Department of
Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences, Thrissur- 680 651, Kerala
Veterinary and Animal Sciences University, Wayanad, Kerala India

Year: 2024, Page: 848-844, Doi: https://doi.org/10.51966/jvas.2024.55.4.842-844

Received: Sept. 27, 2024 Accepted: Oct. 23, 2024 Published: Dec. 31, 2024

Abstract

Kerala has recently experienced a surge in rabies cases despite ongoing vaccination efforts, prompting a need
to assess the efficiency of these vaccinations. This cross-sectional study evaluated the effect of age on post-vaccination
rabies antibody levels in 250 pet dogs in Thrissur district. Dogs were categorised into three: less than one year, one to
five years, and above five years, and the immune response was measured using an indirect ELISA. The study found that
76.4 per cent of the dogs had protective antibody titres (≥0.5 EU/mL) with an average titre of 2.04 EU/mL. Dogs over
five years had the highest seroconversion rate (92.3 per cent), while the younger age groups showed comparatively
lower rates. Age significantly influenced vaccine response, while multiple-dose recipients showed higher protection than
single-dose recipients. The study underscores the importance of booster doses and regular sero-monitoring for effective
rabies control.

Keywords: Anti-rabies vaccination, age, iELISA, antibody titre

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Cite this article

Vani, V., Nair, S. R., Sreekumar, E., Priya, P. M., Mani, B. K., Justin Davis, K. 2024. Effect of age on anti-rabies
immune response in pet dogs of Thrissur district, Kerala, India: a cross-sectional study.
J. Vet. Anim. Sci. 55 (4):842-844

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