Volume: 52 Issue: 3
Year: 2021, Page: 234-237, Doi: https://doi.org/10.51966/jvas.2021.52.3.234-237
Received: Jan. 14, 2021 Accepted: Feb. 27, 2021 Published: Sept. 30, 2021
Conventional treatment modalities usually fail to heal wounds in diabetic animals. Photomodulation of the wound bed using low-level laser has proved its efficacy in treating chronic wounds. Considering the fact that the majority of the diabetic wounds end up in amputation of affected part and reduce the quality of life of the patient, the present study was undertaken to find out the efficacy of gallium arsenide (GaAs) laser in the healing of full-thickness cutaneous wounds in type 2 diabetic rat models. The study was conducted in six adult male Wistar rats with an average body weight of 150 g in which hyperglycemia coexisting with hyperlipidemia was induced. Two wounds of 1 cm2 area were induced of which left side wounds served as the control and right side wounds were treated with GaAs laser at 4J/cm2 area for one minute continuously for four days.
Keywords: Type 2 diabetes, streptozotocin, GaAs laser
Fraser, B., 2020 The colour of wounds and its implication for healing. Available at http://healthtimes.com.au/hub/ wound-care/59/practice/bfl/the-colourof-wounds-and-its-implication-forhealing/45/[13 October 2020]
Grey, J. E., Enoch, S. and Harding, K. G. 2006. ABC of wound healing: wound assessment. Br. Med. J. Practice. 332: 285-288.
Hawkins, D., Houreld, N. and Abrahamse, H., 2005. Low level laser therapy (LLLT) as an effective therapeutic modality for delayed wound healing. Ann. N. Y. Acad. Sci. 1056: 486-493.
Jothi, N. A., Thilagar, S., Omar, A. R. S., Kamaruddin, M. D., Shanthi, G., Goh, Y. M. and Sabri, M. Y. 2007. Effects of biomaterials keratin-gelatin and basic fibroblast growth factor-gelatin composite film on wound healing in dogs. J. Vet. Malaysia 18: 21-26.
Karri, V.V.S.R., Kuppusamy, G., Talluria, S.V., Mannemala, S.S., Kollipara, R., Wadhwani, A.D., Mulukutla, S., Raju, K.R.S. and Malayandi, R. 2016. Curcumin loaded chitosan nanoparticles impregnated into collagen-alginate scaffolds for diabetic wound healing. Int. J. Biol. Macromolec. 93:1519–1529.
Kirubanandan, S. and Sehgal, P. 2010. Regeneration of soft tissue using porous bovine collagen scaffold. J. Optoelectr. Biomed. Mat. 2: 141-149.
Lazovic, G., Colic, M., Grubor, M. and Jovanovic, M., 2005. The application of collagen sheet in open wound healing. Annals of burns and fire disasters, 18:151.
Mitra, T., Manna, P. J., Raja, S. T. K., Gnanamani, A. and Kundu, P. P. 2015. Curcumin loaded nano graphene oxide reinforced fish scale collagen–a 3D scaffold biomaterial for wound healing applications. RSC Adv. 5: 98653-98665.
Posten, W., Wrone, D. A., Dover, J. S., Arndt, K. A., Silapunt, S. and Alam, M. 2005. Lowlevel laser therapy for wound healing: mechanism and efficacy. Dermatol. Surg. 31: 334-340.
Reddy, M., Gill, S. S., Wu, W., Kalkar, S. R. and Rochon, P. A. 2012. Does this patient have an infection of a chronic wound? J. Am. Med. Assoc. 307: 605-611.
Suman, R. K., Mohantey, I. R, Bordey, M. K., Maheswari, U. and Deshmukh, Y. A. 2016. Development of an experimental model of diabetes co-existing with metabolic syndrome in rats. Adv Pharmacol. Sci. Available: http//dx.doi. org/10.1155/2016/9463476 05/01/2018
Varghese, R. 2002. Studies on the effect of Helium-Neon laser on healing of chronic wounds in dogs. MVSc thesis, Tamilnadu Veterinary and Animal Sciences University, Chennai, 65p.
© 2021 Nekha et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Nekha, K.P., Dinesh, P.T., Sooryadas, S., Varghese, R. and Pradeep, M. 2021. Healing of cutaneous wounds using GaAs laser in diabetic rat models. J. Vet. Anim. Sci. 52(3): 234-237.
DOI: https://doi.org/10.51966/jvas.2021.52.3.234-237