Volume: 54 Issue: 4
Year: 2023, Page: 1127-1130, Doi: https://doi.org/10.51966/jvas.2023.54.4.1127-1130
Received: April 5, 2023 Accepted: July 23, 2023 Published: Dec. 31, 2023
A study was conducted in twelve glaucomatous dogs to assess the efficacy of the combination of dorzolamide and timolol in the treatment of glaucoma in dogs. The study included twelve dogs with glaucoma of any age, breed, or gender. On the day of presentation, the 14th, 28th and 42nd days, the intraocular pressure (IOP) was monitored with an applanation tonometer. For 42 days, all dogs received topical instillation of a combination of dorzolamide (2%) and timolol (0.5%) eye drops, one drop twice daily. In all the dogs, there was a shift in IOP towards the established normal level within two weeks of therapy. The study revealed that topical use of a combination of dorzolamide and timolol eye drops twice daily was successful in lowering IOP in dogs with glaucoma.
Keywords: Glaucoma, dorzolamide, timolol, dogs, IOP
Antonia, N. A., Narayanan, M. K., Anoop, S., Devanand, C. B., Martin, J. and Venugopal, S. K. 2014. Occurrence of ophthalmic disorders in dogs. Indian J. Vet. Res. 23: 21-24.
Blocker, T., Hoffman, A., Schaeffer, D. J., and Wallin, J. A. 2007. Corneal sensitivity and aqueous tear production in dogs undergoing evisceration with intraocular prosthesis placement. Vet. Ophthalmol. 10: 147–154.
Casson, R. J., Chidlow, G., Wood, J. P., Crowston, J. G. and Goldberg, I. 2012. Definition of glaucoma: clinical and experimental concepts. Clin. Experiment. Ophthalmol. 40: 341-349.
Komáromy, A. M., Bras, D., Esson, D. W., Fellman, R. L., Grozdanic, S. D., Kagemann, L., Miller, P. E., Moroi, S. E., Plummer, C. E., Sapienza, J. S. and Storey, E. S. 2019. The future of canine glaucoma therapy. Vet. Ophthalmol. 22: 726-740.
Lavanya, B. 2021. Ultrasonographic ocular biometry for the diagnosis of ophthalmic disorders in dogs. M.V.Sc. thesis, Kerala Veterinary and Animal Sciences University, Pookode, 29p.
Maggio, F. 2015. Glaucomas. Top. Companion Anim. Med. 30: 86-96.
Maślanka, T. and Zuśka-Prot, M. 2017. A review of the pharmacology of osmotic agents for the treatment of glaucoma in dogs. J. Hell. Vet. Medical Soc. 68: 501-506.
Michaud, J. E., Friren, B. and International Brinzolamide Adjunctive Study Group. 2001. Comparison of topical brinzolamide 1% and dorzolamide 2% eye drops given twice daily in addition to timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension. Am. J. Ophthalmol. 132: 235-43.
Miller, P. E. and Bentley, E. 2015. Clinical Signs and Diagnosis of the Canine Primary Glaucomas. Vet. Clin. North Am. Small Anim. Pract.45: 1183- 1212.
Park, Y. W., Jeong, M. B., Park, S., Kim, W. T., Kim, S. E., Ahn, J. S. and Seo, K. M., 2012. A Retrospective Study of Primary Glaucoma in Dogs: 43 cases (2006~ 2009). J. Vet. Clin. 29: 38-42.
Plummer, C. E., MacKay, E. O., and Gelatt, K. N. 2006. Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs. Vet. Ophthalmol. 9: 245–249.
Priya, P. 2009. Evaluation and management of glaucoma in dogs. M.V.Sc. thesis. Kerala Veterinary and Animal Sciences University, Pookode, 108p.
Scardillo, A., Pugliese, M., De Majo, M., Niutta, P.P. and Pugliese, A. 2010. Effects of topical 0.5% levobunolol alone or in association with 2% dorzolamide compared with a fixed combination of 0.5% timolol and 2% dorzolamide on intraocular pressure and heart rate in dogs without glaucoma. Vet. Ther. 11: E1-E6.
Shanthala, H. 2018. Comparative evaluation of travoprost and trabeculectomy in the management of glaucoma in dogs. M. V. Sc Thesis, Kerala Veterinary and Animal Sciences University, Pookode, 98p.
Tramontin, M. H., Montiani-Ferreira, F. and Froes, T. R. 2014. Ocular echobiometry in glaucomatous dogs. Arq. Bras. Med. Vet. Zootec. 66:1080-1088.
Weinreb, R. N. and Khaw, P. T. 2004. Primary open-angle glaucoma. Lancet, 363:1711-1720
© 2023 Raut et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Raut, S.W.,Venugopal, S.K., Philip, L.M., John Martin,K.D., George, A. and Joy, G. 2023. Management of canine glaucoma using a combination of dorzolamide and timolol. J. Vet. Anim. Sci. 54(4):1127-1130
DOI: https://doi.org/10.51966/jvas.2023.54.4.1127-1130