Volume: 54 Issue: 1
Year: 2023, Page: 21-29, Doi: https://doi.org/10.51966/jvas.2023.54.1.21-29
Received: May 21, 2022 Accepted: Dec. 3, 2022 Published: March 31, 2023
Cystic echinococcosis (CE) is a dreadful zoonotic neglected disease that affects public health globally. The infection is highly endemic in northern India (Kashmir valley). The present survey based study was done to know the seroprevalence of cystic echinococcosis infection among residents of north and central Kashmir valley and to identify risk variables linked to this infection. In addition to collecting 462 serum samples (244 males and 218 females), a questionnaire was also filled out for each participant utilizing systematic random sampling from June to November 2019 in 16 villages and 6 districts. Using a commercial enzyme-linked immunosorbent assay (ELISA) kit, the samples were tested for immunoglobulin G. Of the 462 serum samples obtained, 33 (7.14 percent) were found to be positive. Results showed that age group, gender, contact with dogs, occupation, and literacy rate were significantly related with the rate of seroprevalence of cystic echinococcosis infection in Central and North Kashmir. Statistics showed that the observations were significant (P< 0.05). Children, men, and those who were uneducated had considerably greater rates of seropositivity for this infection.
Keywords: Zoonotic, seroprevalence, ELISA, immunoglobulin G
Bai, Y., Cheng, N., Jiang, C., Wang, Q. and Cao, D. 2002. Survey on cystic echinococcosis in Tibetans, West China. Acta Trop. 82: 381-385.
Battelli, G. 2009. Echinococcosis: costs, losses and social consequences of a neglected zoonosis. Vet. Res. Commun. 33: 47-52.
Bchir, A., Hamdi, A., Jemni, L., Dazza, M.C., Allegue, M., Braham, M.S., Prazuck, T., Achour, H., Gaudebout, C., Rousset, J.J. and Jemmali, M. 1988. Serological screening for hydatidosis in households of surgical cases in central Tunisia. Ann. Trop. Med. Parasitol. 82: 271-273.
Brehm, K., Kern, P., Hubert, K. and Frosch, M. 1999. Echinococcosis from every angle. Parasitol. Today (Personal ed.). 5: 351-352.
Carmena, D., Benito, A. and Eraso, E. 2007. The immunodiagnosis of Echinococcus multilocularis infection. Clin. Microbiol. Infect. 13: 460-475.
Chirag, S., Fomda, B.A., Khan, A., Malik, A.A., Lone, G.N., Khan, B.A. and Zahoor, D. 2015 Detection of hydatid-specific antibodies in the serum and urine for the diagnosis of cystic echinococcosis in patients from the Kashmir Valley, India. J. Helminthol. 89: 232-237.
Cohen, H., Paolillo, E., Bonifacino, R., Botta, B., Parada, L., Cabrera, P., Snowden, K., Gasser, R., Tessier, R., Dibarboure, L. and Wen, H. 1998. Human cystic echinococcosis in a Uruguayan community: a sonographic, serologic, and epidemiologic study. Am. J. Trop. Med. Hyg. 59: 620-627.
Craig, P.S., Giraudoux, P., Shi, D., Bartholomot, B., Barnish, G., Delattre, P., Quere, J.P., Harraga, S., Bao, G., Wang, Y. and Lu, F. 2000. An epidemiological and ecological study of human alveolar echinococcosis transmission in south Gansu, China. Acta trop. 77: 167-177.
Eckert, J. and Deplazes, P. 2004. Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern. Clin. Microbiol. Rev.17: 107-135.
Eckert, J., Gemmell, M.A., Meslin, F.X., Pawlowski, Z.S. World Health Organization. 2001. WHO/OIE manual on echinococcosis in humans and animals: a public health problem of global concern. World Organisation for Animal Health. 286p.
Fakhar, M. and Sadjjadi, S.M. 2007. Prevalence of hydatidosis in slaughtered herbivores in Qom Province, central part of Iran. Vet. Res. Commun. 31: 993.
Faul, F.; Erdfelder, E.; Lang, AG. & Buchner, A. 2007. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods. 39: 175-191.
Fomda, B.A., Khan, A., Thokar, M.A., Malik, A.A., Fazili, A., Dar, R.A., Sharma, M. and Malla, N. 2015. Sero-Epidemiological survey of human cystic echinococcosis in Kashmir, North India. PLoS One. 10: e0124813.
Harandi, M.F., Moazezi, S.S., Saba, M., Grimm, F., Kamyabi, H., Sheikhzadeh, F., Sharifi, I. and Deplazes, P. 2011. Sonographical and serological survey of human cystic echinococcosis and analysis of risk factors associated with seroconversion in rural communities of Kerman, Iran. Zoonoses Public Hlth. 58: 582-588.
Heidari, Z., Mohebali, M., Zarei, Z., Aryayipour, M., Eshraghian, M.R., Kia, E.B., Shodajei, S., Abdi, J., Rakhshanpour, A. and Rokni, M.B. 2011. Seroepidemiological study of human hydatidosis in Meshkinshahr district, Ardabil province, Iran. Iran. J. Parasitol. 6: 19.
Kaur, M., Mahajan, R.C. and Malla, N. 1999. Diagnostic accuracy of rapid enzyme linked immunosorbent assay for the diagnosis of human hydatidosis. Indian J. Med. Res. 110: 18.
Mandal, S. and Mandal, M.D. 2012. Human cystic echinococcosis: epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects. Asian Pac. j. trop. Med. 5: 253-260.
McManus, D.P. and Smyth, J.D. 1986. Hydatidosis: changing concepts in epidemiology and speciation. Parasitol. Today. 2: 163-168.
Moro, P. and Schantz, P.M. 2009. Echinococcosis: a review. Int. J. Infect. Dis. 13: 125-133.
Moro, P., Verastegui, M., Gilman, R.H., Falcon, N., Bernal, T., Gavidia, C., Gonzalez, A., Malqui, V., Moro, M.H. and Dueger, E. 1997. Enzyme-linked immunoelectrotransfer blot assay for diagnosis of hydatidosis (Echinococcus granulosus) in sheep. Vet. Rec. 140: 605-606.
Mohammed, M.O. 2013. The Human Seroprevalence of Echinococcus Granulosus in Sulaimani Governorate. The Iraqi Postgrad Med. J. 12: 45-50.
World Health Organization. 2011. Report of the WHO informal working group on cystic and alveolar echninococcosis surveillance, prevention and control, with the participation of the Food and Agriculture Organization of the United Nations and the World Organisation for Animal Health, 22-23 June 2011, Department of Control of Neglected Tropical Diseases, WHO, Geneva, Switzerland.
Parikh, F. 2012. Echinococcosis cut to cure but what about control. J. Assoc. Physicians India. 60: 9-10.
Pednekar, R.P., Gatne, M.L., Thompson, R.A. and Traub, R.J. 2009. Molecular and morphological characterisation of Echinococcus from food producing animals in India. Vet. Parasitol.165: 58-65.
Rahimi, M.T., Sharifdini, M., Ahmadi, A., Laktarashi, B., Mahdavi, S.A. and Kia, E.B. 2011. Hydatidosis in human and slaughtered herbivores in Mazandaran province, northern Iran. Asian Pac. J. Trop. Med. 1: 212-215.
Rajaji, M. 2005. Comparison of ELISA and IHA diagnostic tests in the detection of human hydatidosis in Tabriz. Int. Med. J. 4: 14-16.
Regassa, F., Molla, A. and Bekele, J. 2010. Study on the prevalence of cystic hydatidosis and its economic significance in cattle slaughtered at Hawassa Municipal abattoir, Ethiopia. Trop. Anim. Health Prod. 42: 977-984.
Salem, C.O.A., Schneegans, F., Chollet, J.Y. and et Jemli, M.H. 2011. Epidemiological studies on echinococcosis and characterization of human and livestock hydatid cysts in mauritania. Iran. J. Parasitol. 6: 49.
Sbihi, Y., Janssen, D. and Osuna, A. 1996. Serologic recognitionof hydatid cyst antigens using different purification methods. Diagn. Microbiol. Infect. Dis. 24: 205-211.
Shambesh, M.K., L. Macpherson, C.N., Beesley, W.N., Gusbi, A. and Elsonosi, T. 1992. Prevalence of human hydatid disease in northwestern Libya: a cross-sectional ultrasound study. Ann. Trop. med. Parasitol. 86: 381-386.
Sréter, T., Széll, Z., Egyed, Z. and Varga, I. 2003. Echinococcus multilocularis: an emerging pathogen in Hungary and Central Eastern Europe. Emerg. Infect. Dis. 9: 384.
Saida, L.A. and Nouraddin, A.S. 2011. Epidemiological study of cystic echinococcosis in Man and slaughtered Animals in Erbil province, Kurdistan Regional-Iraq. Tikrit J. Pure sci. 16: 45-50.
Thompson, R.C.A. 1995. Biology and systematics of Echinococcus. Echinococcus and hydatid disease.
Todorov, T. and Boeva, V. 1999. Human echinococcosis in Bulgaria: a comparative epidemiological analysis. Bull. World Health Organ. 77: 110.
Wang, Q., Huang, Y., Huang, L., Yu, W., He, W., Zhong, B., Li, W., Zeng, X., Vuitton, D.A., Giraudoux, P. and Craig, P.S. 2014. Review of risk factors for human echinococcosis prevalence on the Qinghai-Tibet Plateau, China: a prospective for control options. Infect. Dis. Poverty. 3: 1-8.
Wattal, C.H.A.N.D., Malla, N.A.N.C.Y., Khan, I.A. and Agarwal, S.C. 1986. Comparative evaluation of enzyme-linked immunosorbent assay for the diagnosis of pulmonary echinococcosis. J. Clin. Microbiol. 24: 41-46.
Yang, Y.R., Craig, P.S., Vuitton, D.A., Williams, G.M., Sun, T., Liu, T.X., Boufana, B., Giraudoux, P., Teng, J., Li, Y. and Huang, L. 2008. Serological prevalence of echinococcosis and risk factors for infection among children in rural communities of southern Ningxia, China. Trop. Med. Int. Health. 13: 1086-1094.
Zhang, W. and McManus, D.P. 2006. Recent advances in the immunology and diagnosis of echinococcosis. FEMS Microbiol. Immunol. 47: 24-41.
Zibaei, M., Azargoon, A., Ataie-Khorasgani, M., Ghanadi, K. and Sadjjadi, S.M. 2013. The serological study of cystic echinococcosis and assessment of surgical cases during 5 years (2007-2011) in Khorram Abad, Iran. Niger. J. Clin. Pract. 16: 221-225.
© 2023 Andrabi et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Andrabi,A.,Tak,H., Muzamil,W., Fomda,B., Para,B.A., Shah,I.M. and Majeed,I. 2023 Seroprevalence and risk factors of human cystic echinococcosis in Central and North Kashmir, India. J. Vet. Anim. Sci. 54(1):21-29
DOI: https://doi.org/10.51966/jvas.2023.54.1.21-29