JVAS announces awards - Four best research articles (one each from basic, production, para-clinical and clinical subjects) and one best short communication will be adjudged for awards each year!!!

Journal of Veterinary and Animal Sciences

Volume: 57 Issue: 2

  • Open Access
  • Research Article

Therapeutic efficacy of Ovsynch and progesterone based protocol in goats with ovarian follicular cyst

S. Shruthi1, Amritha Aravind,1 C. Jayakumar1, Hiron M. Harshan1 R.S. Abhilash 1 and M.V. Chinnu2

1Department of Animal Reproduction Gynaecology and Obstetrics, COVAS, Mannuthy, Thrissur-680651, 2University Veterinary Hospital, Kokkalai , Thrissur, Kerala Veterinary and Animal Sciences University, Pookode, Wayanad, India

Year: 2026, Page: 317-322, Doi: https://doi.org/10.51966/jvas.2026.57.2.317-322

Received: Feb. 7, 2026 Accepted: April 10, 2026 Published: June 30, 2026

Abstract

Ovarian follicular cysts are an important cause of infertility in goats, yet limited information is available regarding their clinico-endocrine characteristics and therapeutic management. Fourteen goats with follicular cysts were evaluated using ultrasound and were treated with two protocols: Ovsynch (Group I, n=6) and intravaginal progesterone sponge (Group II, n=8). Affected goats had a mean age of 2.4 ± 0.27 years and body condition score of 2.5–3.5. Follicular cysts were either solitary with mean size of 11.0 ± 0.9 mm or multiple having a mean size of 9.50 ± 0.27 mm. The mean wall thickness of cyst was 1.10 ± 0.023 mm and the uterus was uniformly hypoechoic with occasional luminal contents. Serum oestradiol concentration was 41.78 ± 4.26 pg/dL and 36.74 ± 3.11 pg/dL in group I and group II, respectively, in affected goats and following treatment the mean values were 42.38 ± 6.67 pg/dL in Group I and 40.51 ± 3.64 pg/dL in Group II at induced oestrus. Mean progesterone level was 0.62 ± 0.28 ng/mL on the day of presentation and remained <1 ng/mL at induced oestrus in both the groups. Post-treatment fate of cyst revealed regression (16.7% Group I; 12.5% Group II), luteinisation (50% both groups) and persistence (33.3–37.5%). Dominant follicles were detected in 50 percent of goats in both the groups following therapy with non-significant difference in the mean size (7.35 ± 0.51 mm in Group I; 6.90 ± 0.54 mm in Group II). Conception rates at induced oestrus were 16.67 and 50 per cent, respectively, indicating better outcomes with the intravaginal progesterone sponge protocol.

Keywords: Goat, Ovarian follicular cyst, Ultrasonography, Ovsynch, Intravaginal Progesterone sponge

References

Aiswarya, D. (2024). Intravaginal and injectable progesterone primed protocol incorporating human chorionic gonadotropin and gonadotropin releasing hormone for oestrus induction in postpartum malabari goats [Master's thesis, Kerala Veterinary and Animal Sciences University].

Allam, T. S., Abd El-Razek, E. M., & Saleh, N. S. (2019). Ovarian cysts in dairy cows: Treatment trials in relation to changes in hematological, biochemical and hormonal parameters. Journal of Reproduction and Infertility, 10(1), 7–17. https://doi.org/10.5829/idosi.jri.2019.07.17

Al-Wan, A. F., & Amine, F. A. (2010). Anatomical and histological lesions causing infertility in local goats (Sulaimania Region). Al-Qadisiya Journal of Veterinary Medical Sciences. https://doi.org/10.29079/vol9iss3art134

Balaro, M. F. A., Cosentino, I. O., Ribeiro, A. C. S., & Brandao, F. Z. (2022). Ultrasound diagnosis in small ruminants: Occurrence and description of genital pathologies. https://doi.org/10.3390/vetsci9110599

Bareera, V. (2022). Induction of oestrus using long-term and short-term progesterone based protocols in anoestrous goats [Master's thesis, Kerala Veterinary and Animal Sciences University].

Beena, V., Pawaiya, R. V. S., Shivasharanappa, N., Gururaj, K., Gupta, V. K., Gangwar, N. K., Singh, D. D., Karikalan, M., Sharma, A. K., Kumar, H., & Kumar, A. (2015). Occurrence of pathological conditions in the female genitalia of goats. Indian Journal of Veterinary Pathology, 39, 197–201. https://doi.org/10.5958/0973-970X.2015.00049.8

Chemineau, P., Gauthier, D., Poirier, J. C., & Saumande, J. (1982). Plasma levels of LH, FSH, prolactin, oestradiol-17β and progesterone during natural and induced oestrus in the dairy goat. Theriogenology, 17(3), 313–323. https://doi.org/10.1016/0093-691x(82)90091-7

Fonseca, J. F., & Torres, C. A. A. (2005). Administration of hCG 5 days after breeding and reproductive performance in nulliparous dairy goats. Reproduction in Domestic Animals, 40(6), 495–499. https://doi.org/10.1111/j.1439-0531.2005.00612.x

Gupta, C., Ramprabhu, R., Sabarinathan, A., Kumar, S. G., & Prabaharan, V. (2024). Management of hydrometra with or without ovarian follicular cysts in goats. Indian Journal of Small Ruminants, https://doi.org/10.5958/0973-9718.2024.00039.4

Khan, M. I. U. R., Ejaz-ul-Haq, M., Rehman, A., Mohsin, I., Hassan, M., Ahmad, N., & Kausar, R. (2016). Diagnosis of ovarian follicular cyst in a Beetal goat by ultrasonography and treatment with GnRH-PGF₂α. Pakistan Veterinary Journal, 37(1), 120–122. https://www.pvj.com.pk/pdf-files/37_1/120-122.pdf

Kouamo, J., & Asongafec, T. B. (2020). Prevalence and associated risk factors of genital abnormalities of does and ewes in the West Region of Cameroon. PSM Veterinary Research, 5(3), 81–96. https://psmjournals.org/index.php/vetres/article/view/470

Laporte, H. M., Hogeveen, H., Schukken, Y. H., & Noordhuizen, J. P. T. M. (1994). Cystic ovarian disease in Dutch dairy cattle. I. Incidence, risk factors and consequences. Livestock Production Science, https://doi.org/10.1016/0301-6226(94)90170-8

Margatho, G., Rodriguez-Estevez, V., Quintas, H., & Simões, J. (2019). The effects of reproductive disorders, parity, and litter size on milk yield of Serrana goats. Animals, 9(11), 968. https://doi.org/10.3390/ani9110968

Medan, M. S., Watanabe, G., Sasaki, K., & Taya, K. (2004). Transrectal ultrasonic diagnosis of ovarian follicular cysts in goats and treatment with GnRH. Domestic Animal Endocrinology. https://doi.org/10.1016/j.domaniend.2004.03.006

Murtaza, A., Khan, M. I. U. R., Ahmad, W., Sohail, T., Mohsin, I., Shahzad, M., & Ijaz, M. (2019). Follicular dynamics and changes in plasma estradiol-17β and progesterone concentrations during estrous cycle in Beetal goats. Pakistan Veterinary Journal, 39(2), 193-198. https://doi.org/10.29261/pakvetj/2019.046

Shringi, A., Mandovera, V., Gahlot, M., Saini, R. K., & Vyas, I. (2016). Gross and histopathological observation of cystic ovarian degeneration in goats (Capra hircus). Veterinary Practitioner, 17(1).

Simoes, J., Baril, G., Azevedo, J., & Mascarenhas, R. (2009). Ovarian cysts (persistent follicles) and ultrasonographic texture of uterus in a nulliparous and a primiparous goats.Veterinaria.com.pt,1,1-8. https://www.researchgate.net/publication/228462104_Ovarian_cysts_persistent_follicles_and_ultrasonographic_texture_of_uterus_in_a_nulliparous_and_a_primiparous_goats

Todoroki, J., Noguchi, J., Kikuchi, K., Ohnuma, K., Ozawa, M., & Kaneko, H. (2004). Plasma concentrations of inhibin A in cattle with follicular cysts: Relationships with turnover of follicular waves and plasma levels of gonadotropins and steroid hormones. Domestic Animal Endocrinology, 27(4), 333–344.

Vanholder, T., Opsomer, G., & De Kruif, A. (2006). Aetiology and pathogenesis of cystic ovarian follicles in dairy cattle: A review. Reproduction Nutrition Development, 46(2), 105–119. https://doi.org/10.1051/rnd:2006003

Wiltbank, M., Lopez, H., Sartori, R., Sangsritavong, S., & Gümen, A. (2006). Changes in reproductive physiology of lactating dairy cows due to elevated steroid metabolism.Theriogenology, https://doi.org/10.1016/j.theriogenology.2005.10.003

Cite this article

Shruthi S., Aravind A., Jayakumar C., Harshan H.M., Abhilash R.S. & Chinnu M.V. (2026). Therapeutic efficacy of Ovsynch and progesterone based protocol in goats with ovarian follicular cyst. Journal of Veterinary and Animal Sciences, 57(2),317-322 https://doi.org/10.51966/jvas.2026.57.2.317-322

Views
9
Downloads
4
Citations