Volume: 56 Issue: 1
Year: 2025, Page: 45-52, Doi: https://doi.org/10.51966/jvas.2025.56.1.45-52
Received: Sept. 24, 2024 Accepted: Dec. 26, 2024 Published: March 31, 2025
Foot-and-mouth disease (FMD) is a highly contagious viral infection affecting cloven-footed animals, including cattle, sheep, goats, pigs, and wildlife. This study developed a system dynamics compartmental model to elucidate the transmission dynamics of FMD in cattle. Key parameters influencing disease spread such as the basic reproduction number (R0), duration of infectivity, and immunisation coverage were identified through a thorough literature review and integrated into the model, which comprised Susceptible (S), Infectious (I), and Recovered (R) compartments. The analysis focused on the effects of varying R0 values, infectivity durations, and vaccination rates on disease transmission. Findings highlighted the critical role of reducing R0 and increasing vaccination coverage to mitigate FMD outbreaks and enhance control measures.
Keywords: Foot and mouth disease, models, simulation, transmission dynamics, basic reproduction number
Azeem, A., Rashid, I., Hassan, M.M., Asad, M., Kaukab, G., Tehseen, A. and Aamir, S. 2020. 10. A review on foot and mouth disease in dairy animals, etiology, pathogenesis and clinical findings. Pure Appl. Biol. 9(1): 821-832.
Belayneh, N., Molla, W., Mesfine, M. and Jemberu, W.T. 2020. Modeling the transmission dynamics of foot and mouth disease in Amhara region, Ethiopia. Prev. Vet. Med. 181: 104673. Available: https://doi.org/10.1016/j.prevetmed.2019.04.002 [Aug. 2020].
Calder, M., Craig, C., Culley, D., De Cani, R., Donnelly, C.A., Douglas, R., Edmonds, B., Gascoigne, J., Gilbert, N., Hargrove, C. and Hinds, D. 2018. Computational modelling for decision-making: where, why, what, who and how. Royal Soc. Open Sci. 5(6): 172096. Available: https://doi.org/10.3389/frai.2022.750763 [Feb. 2022].
Capon, T.R., Garner, M.G., Tapsuwan, S., Roche, S., Breed, A.C., Liu, S., Miller, C., Bradhurst, R. and Hamilton, S. 2021. A simulation study of the use of vaccination to control foot-and-mouth disease outbreaks across Australia. Front. Vet. Sci. 8: 648003. Available: https://doi.org/10.3389/fvets.2021.648003 [11 Aug. 2021]
DAHD. 2019. 20th Livestock Census. All India Report published by Department of Animal Husbandary and Dairying, Government of India. Available: https://dahd.nic.in/about-us/divisions/statistics
De Rueda, C.B., Dekker, A., Eble, P.L. and De Jong, M.C.M. 2015. Vaccination of cattle only is sufficient to stop FMDV transmission in mixed populations of sheep and cattle. Epidemiol. Infect. 143(11): 2279-2286.
Edo, J.J. and Bekele, J.T. 2019. A review on trans-boundary animal diseases management. Vet. Res. 12(1): 1-9.
Ferguson, N.M., Donnelly, C.A. and Anderson, R.M. 2001. The foot-and-mouth epidemic in Great Britain: pattern of spread and impact of interventions. Sci. 292(5519): 1155-1160.
Gibson, A.J., Paton, D.J. and Werling, D. 2021. Vaccination Strategies, Implementation, and Monitoring. Vet. Vaccines: Principles and Applications. (1st Ed.). Wiley- Blackwell, United Kingdom, 442p.
Gunasekera, U., Biswal, J.K., Machado, G., Ranjan, R., Subramaniam, S., Rout, M., Mohapatra, J.K., Pattnaik, B., Singh, R.P., Arzt, J. and Perez, A. 2022. Impact of mass vaccination on the spatiotemporal dynamics of FMD outbreaks in India, 2008–2016. Transbound. Emerg. Dis. 69(5): 1936-1950.
Hayer, S.S., Ranjan, R., Biswal, J.K., Subramaniam, S., Mohapatra, J.K., Sharma, G.K., Rout, M., Dash, B.B., Das, B., Prusty, B.R. and Sharma, A.K. 2018. Quantitative characteristics of the foot‐and‐mouth disease carrier state under natural conditions in India. Transbound. Emerg. Dis. 65(1): 253-260.
Heffernan, J.M., Smith, R.J. and Wahl, L.M. 2005. Perspectives on the basic reproductive ratio. J. R. Soc. Interface. 2(4): 281-293.
Islam, M.S., Habib, M.A., Islam, M.R., Mahmud, M.S., Saha, P.C., Ruba, T., Das, P.M. and Khan, M.A. 2017. Clinicopathological investigation of foot and mouth disease and serotype identification of the viruses in cattle of Bangladesh. Immunol. Infect. Dis. 5(2): 16-23.
James, A.D. and Rushton, J. 2002. The economics of foot and mouth disease. Rev. Sci. Tech. - Off. Int. Epizoot. 21(3): 637-641.
Keeling, M.J. 2005. Models of foot-and-mouth disease. Proc. R. Soc. B. 272(1569): 1195-1202.
Krishnamoorthy, P., Suresh, K.P., Dheeraj, R. and Roy, P. 2020. Basic reproduction number (R0), an epidemiological tool for prioritizing livestock diseases' an example of Karnataka. Indian J. Anim. Sci. 90(4): 510-514.
Mardones, F., Perez, A., Sanchez, J., Alkhamis, M. and Carpenter, T. 2010. Parameterization of the duration of infection stages of serotype O foot-and-mouth disease virus: an analytical review and meta-analysis with application to simulation models. Vet. Res. 41(4): 45. Available: https://doi.org/10.1051%2Fvetres%2F2010017 [8 Mar. 2010].
McLachlan, I., Marion, G., McKendrick, I.J., Porphyre, T., Handel, I.G. and Bronsvoort, B.D. 2019. Endemic foot and mouth disease: pastoral in-herd disease dynamics in sub-Saharan Africa. Sci. Rep. 9(1): 17349. Available: https://doi.org/10.1038/s41598-019-53658-5 [22 Nov. 2019].
Mushayabasa, S., Bhunu, C.P. and Dhlamini, M. 2011. Impact of vaccination and culling on controlling foot and mouth disease: a mathematical modelling approach. Wld. J. Vaccines. 1:156-161.
Orsel, K. and Bouma, A. 2009. The effect of foot-and-mouth disease (FMD) vaccination on virus transmission and the significance for the field. Can. Vet. J. 50(10): 1059–1063.
Parida, S. 2009. Vaccination against foot-and-mouth disease virus: strategies and effectiveness. Expert Rev. Vaccines. 8(3): 347-365.
Shamsuddoha, M. and Nedelea, A.M. 2013. A Vensim based analysis for supply chain model. Ecoforum. 2(2): 49-54.
Sharma, G.K., Mahajan, S., Matura, R., Biswal, J.K., Ranjan, R., Subramaniam, S., Misri, J., Bambal, R.G. and Pattnaik, B. 2017. Herd immunity against foot‐and‐mouth disease under different vaccination practices in India. Transbound. Emerg. dis. 64(4): 1133-1147.
Subramaniam, S., Pattnaik, B., Sanyal, A., Mohapatra, J.K., Pawar, S.S., Sharma, G.K., Das, B. and Dash, B.B. 2013. Status of Foot‐and‐mouth Disease in India. Transbound. Emerg. Dis. 60(3): 197-203.
Tadesse, B., Molla, W., Mengsitu, A. and Jemberu, W.T. 2019. Transmission dynamics of foot and mouth disease in selected outbreak areas of northwest Ethiopia. Epidemiol. Infect. 147: 189.
Tang, V. and Vijay, S. 2001. System dynamics. Origins, development, and future prospects of a method. Res. Seminar. Engineering. Syst. 83: 1-12.
Van den Driessche, P. and Watmough, J. 2008. Further notes on the basic reproduction number. Math. Epidemiol. 1: 159-178.
Woolhouse, M.E. 2003. Foot‐and‐mouth disease in the UK: What should we do next time? J. Appl. Microbiol. 94(s1): 126-130.
Yadav, S., Stenfeldt, C., Branan, M.A., Moreno-Torres, K.I., Holmstrom, L.K., Delgado, A.H. and Arzt, J. 2019. Parameterization of the durations of phases of foot-and-mouth disease in cattle. Front. Vet. Sci. 6: 263. Available: https://doi.org/10.3389/fvets.2019.00263 [9 Aug. 2019].
© 2025 Aparna et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aparna, P.A., Davis, J.K., Kaniyamattam, K., Tresamol, P.V., Vinodkumar, K., and Jolly, D. 2025. Analyzing the dynamics of Foot-and-Mouth Disease transmission: A model-based approach.
J. Vet. Anim. Sci. 56 (1):45-52