Journal of Veterinary and Animal Sciences

Volume: 55 Issue: 1

  • Open Access
  • Short Communication

Haematobiochemical alterations observed in acute pancreatitis induced by L-arginine in rat

Aravind K. Unni1, K.S. Prasanna1*, S.S. Devi1, B. Dhanush Krishna1, Suresh N. Nair2, A. Rajendra Prasad3, R. Bharathi1 and S. Sruthi6

1. Department of Veterinary Pathology

2. Department of Veterinary Pharmacology and Toxicology

College of Veterinary and Animal Science, Mannuthy, Thrissur - 680 651 Kerala Veterinary and Animal Sciences University Kerala, India

3. Department of Animal Breeding and Genetics, PVNRTVU

*Corresponding author: [email protected], Ph. 8589904780

Year: 2024, Page: 222-225, Doi: https://doi.org/10.51966/jvas.2024.55.1.222-225

Received: Oct. 16, 2023 Accepted: Dec. 15, 2023 Published: March 31, 2024

Abstract

Acute pancreatitis is an acute inflammatory condition that primarily affects the exocrine pancreas. Diagnosis and treatment of acute pancreatitis can be aided by evaluating particular haematobiochemical alterations. Twelve Wistar albino rats were split up into two groups. Group 1 served as control, while Group 2 (the experimental group) received two intraperitoneal injections of L-arginine at the dose rate of 2.5 g/Kg body weight on the 14th day of experiment. Haematobiochemical parameters were assessed on days 0, 7, and 15 of the experiment. Group 2 exhibited a significant rise in serum amylase and lipase levels when contrasted with Group 1 (P0.05).

Keywords: Acute pancreatitis, L-arginine, haemato-biochemistry, Wistar albino rats

References

Cridge, H., Twedt, D.C., Marolf, A.J., Sharkey, L.C. and Steiner, J.M. 2021. Advances in the diagnosis of acute pancreatitis in dogs. J. Vet. Intern. Med., 35: 2572-2587.

Gadicherla, V., Challa, S., Basaveswara Rao, M., Kunda, P. and Prudhvi, R. 2019. Morinda citrifolia (Noni) fruit protects the exocrine pancreatic dysfunction against L-arginine induced acute pancreatitis in rats. Pharmacogn. Mag., 15: 328.

Hegyi, P., Perides, G., Steer, M.L. and Rakonczay Jr, Z. 2013. Commonly employed rodent models of experimental acute pancreatitis: their strengths and weaknesses, relevance to human disease, selection, and appropriate use. Pancreapedia: The Exocrine Pancreas Knowledge Base. 1: Available doi: 10.3998/panc.2013.4.pdf. [18 Apr. 2023].

Hess, R.S., Saunders, H.M., Van Winkle, T.J., Shofer, F.S. and Washabau, R.J., 1998. Clinical, clinicopathologic, radiographic, and ultrasonographic abnormalities in dogs with fatal acute pancreatitis: 70 cases (1986-1995). J. Am. Vet. Med. Assoc.213: 665-670.

Khurana, A., Sikha, M.S., Ramesh, K., Venkatesh, P. and Godugu, C., 2019. Modulation of ceruleinā€induced pancreatic inflammation by hydroalcoholic extract of curry leaf (Murraya koenigii). Phytotherapy Res., 33: 1510-1525.

Mizunuma, T., Kawamura, S. and Kishino, Y. 1984. Effects of Injecting Excess Arginine on Rat Pancreas. J. Nutr., 114: 467-471.

Trapnell, J.E., 1966. The natural history and prognosis of acute pancreatitis. Annals. R. Coll. of Surgeons of England, 38: 265-287.

Watson, P., 2004. Pancreatitis in the dog: dealing with a spectrum of disease. In Practice26: 64-77

Cite this article

Unni A.K., Prasanna, K.S., Devi, S.S., Krishna, B.D., Nair, S. N., Rajendra Prasad, A., Bharathi, R. and Sruthi, S. 2023. Haematobiochemical changes observed in acute pancreatitis induced by L-arginine in rat. J. Vet. Anim. Sci. 55(1):222-225

DOI: https://doi.org/10.51966/jvas.2024.55.1.222-225

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