Volume: 55 Issue: 3
Year: 2024, Page: 661-663, Doi: https://doi.org/10.51966/jvas.2024.55.3.661-663
Received: Dec. 19, 2023 Accepted: March 30, 2024 Published: Sept. 30, 2024
Tuberculosis in Asian elephants usually shows involvement of lungs and associated lymph nodes. Grossly, the affected lobes of lungs reveal circumscribed lesions of varying sizes with central areas of caseation and necrosis. This report documents histomorphological features of pulmonary tuberculosis in six Asian elephants. The important cell types present were lymphocytes, foamy macrophages, epithelioid macrophages and Langhan’s type of giant cells. In addition, caseation necrosis, fibrotic capsule, and mineralisation (calcification) were also observed. Characteristic features of tuberculoid granulomas observed in the six cases showed similarities with other species. The six cases showed varying proportions of the seven defined features but all features were present together only in one case
Keywords: Granuloma, histopathology
Dartois, V. 2011. Immunopathology of tuberculosis disease across species, In: Leong, F.J., Dartois, V. and Dick, T. (Eds.) A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis. CRC Press Taylor and Francis Group INC, pp. 19-30.
Landolfi, J.A., Terio, K.A., Miller, M., Junecko, B.F. and Reinhart, T. 2015. Pulmonary tuberculosis in Asian elephants (Elephas maximus): histologic lesions with correlation to local immune responses. Vet. Pathol. 52: 535-542.
Lyashchenko, K.P., Greenwald, R., Esfandiari, J., Mikota, S., Miller, M., Moller, T., Vogelnest, L., Gairhe, K.P., Robbe-Austerman, S., Gai, J. and Waters, W.R. 2012. Field application of serodiagnostics to identify elephants with tuberculosis prior to case confirmation by culture. Clin Vaccine Immunol. 19: 1269-75.
Palmer, M.V., Kanipe, C. and Boggiatto PM. 2022. The bovine tuberculoid granuloma. Pathogens. 11: 61.
Sakamoto, K. 2012. The pathology of Mycobacterium tuberculosis infection. Vet. Pathol. 49: 423-439.
Suvarna, K.S., Layton, C. and Bancroft, J.D. 2018. Bancroft's Theory and Practice of Histological Techniques (8th Ed.), Elsevier, Amsterdam. 672p.
© 2024 David Abraham et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
David Abraham, Deepa, P.M., Purnima, C.,. Bipin, K.C, Rajani, C.V., Vijayakumar K. and Anilkumar, T.V. 2024. Histomorphological features of pulmonary tuberculosis in Asian elephants (Elephas maximus). J. Vet. Anim. Sci. 55 (3):661-663