Journal of Veterinary and Animal Sciences

Volume: 55 Issue: 1

  • Open Access
  • Research Article

Histopathological and immunophenotypical classification of canine mammary tumours

Nisna Niyas1, I. S. Sajitha1*, K.S. Prasanna1, S. S. Devi1, Sudheesh S Nair2, A.K. Anseena1 and S. Afsal3

1. Department of Veterinary Pathology

2. Department of Veterinary Surgery and Radiology

College of Veterinary and Animal Science, Mannuthy, Thrissur - 680 651 Kerala Veterinary and Animal Sciences University Kerala, India

3. Animal Husbandry Department   

*Corresponding author: [email protected], Ph. 9446193407

Year: 2024, Page: 122-128, Doi:

Received: Oct. 10, 2023 Accepted: Dec. 12, 2023 Published: March 31, 2024


Canine mammary tumour (CMT) is the most common malignancy reported in intact female dogs. The present study is envisaged to classify the CMTs based on the histopathologic type, grade and hormone receptor status. Twenty-five cases of CMTs were taken as the study material. The excisional biopsy samples from all the cases were collected and processed for histopathology and grading of tumours. The immunohistochemical evaluation of oestrogen receptor (ER) and/or progesterone receptor (PR) or human epidermal growth factor type II receptor (HER2) in CMTs was carried out to classify them. Luminal A had the highest number of cases followed by luminal B. One case of triple negative breast cancer (TNBC) and two cases of HER2 enriched tumours were also noted. All the tumours in HER2 enriched and TNBC were grade 3 with aggressive characters like lymphatic invasion and angiogenesis. The prognosis of the above cases was studied and the data revealed poor prognosis in the HER2 enriched and TNBC compared to luminal A and B. The implementation of targeted therapy in canine mammary tumours based on hormone receptor status may increase the chances of recovery or may prolong the survival period in canine patients.

Keywords: Canine mammary tumours, ER, PR, HER2, TNBC


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Cite this article

Niyas N., Sajitha I.S., Prasanna K.S., Devi S.S., Nair S.S., AnseenaA.K. and Afsal S. 2024. Histopathological and immunophenotypical classification of canine mammary tumours. J. Vet. Anim. Sci. 55(1):122-128