Volume: 56 Issue: 1
Year: 2025, Page: 81-85, Doi: https://doi.org/10.51966/jvas.2025.56.1.81-85
Received: Sept. 28, 2024 Accepted: Dec. 3, 2024 Published: March 31, 2025
Canine leptospirosis is a bacterial infection which has serious consequences in dogs. This study focused on the pathology of leptospira infection in a dog and the immunohistochemical localisation of YKL-40, a biomarker known for its association with inflammation in various tissues. The post-mortem examination revealed severe damage in several organs, particularly the liver, kidneys, lungs, heart and spleen. Histopathological analysis confirmed substantial inflammatory changes such as interstitial pneumonia, and interstitial nephritis with glomerular atrophy and tubular necrosis while PCR and Warthin-Starry staining identified the presence of Leptospira in kidney tissues. Significant localisation of YKL-40 could be noticed in the liver, lungs and kidneys suggesting its potential as a biomarker for early inflammation in leptospirosis. The study confirmed that leptospirosis is one of the infectious causes which could cause multiple organ dysfunction in dogs. YKL-40 plays an important role in diagnosing inflammatory changes associated with infectious diseases like leptospirosis, emphasising its potential for future research into the inflammatory response and offering valuable insights for developing treatments in both animals and humans.
Keywords: Canine leptospirosis, YKL-40, multiple organ dysfunction, histopathological analysis, PCR, Warthin-Starry staining
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© 2025 Anoop et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Anoop E. P., Devi S.S., Prasanna K. S., Anoopraj R, Binu K. Mani and Arun George. 2024. Immunohistochemical localisation of YKL-40 in multiple organ dysfunction associated with leptospirosis in a dog.
J. Vet. Anim. Sci. 56 (1):81-85