Journal of Veterinary and Animal Sciences

Volume: 55 Issue: 1

  • Open Access
  • Short Communication

Impact of mycotoxin deoxynivalenol on antibiotic resistance induction – a proof-ofconcept study

K. Prathap-Kumar1*, S. Narayan2, V.S. Shalmali2, M.N. Balakrishnan-Nair1 and N. Punniyamurthy1

1. Ethno-Veterinary Science and Practice The University of Trans-Disciplinary Health Sciences and Technology (TDU) Bangalore – 560064 Karnataka, India

2. Padmashree Group of Institutions (PGI), Bangalore – 560040

Correspondence author: [email protected], Ph. +918028568000

Year: 2024, Page: 229-232, Doi: https://doi.org/10.51966/jvas.2024.55.1.229-232

Received: Dec. 11, 2023 Accepted: March 1, 2024 Published: March 31, 2024

Abstract

With nearly 60-80 per cent of global food commodities contaminated with mycotoxins, long-time exposure to mycotoxins is highly likely. In-addition to causing toxic effects in humans and animals these mycotoxins are shown to cause gut-microbiota dysbiosis and increased pathogenic bacterial infection. However, despite their antibiotic properties, until now mycotoxins were usually not-suspected to induce resistance to antibiotics (ABR). To provide a proof-of-concept, we carried out experiments using mycotoxin deoxynivalenol (DON) in both extended-spectrum-betalactamase Escherichia coli (ESBLEC) and American-type-culture-collection E. coli (ATCCEC) following standard protocols. In-coherence with the postulate ESBLEC showed induction of ABR against one antibiotic “Piperacillin-Tazobactum” out of 19 tested antibiotics, as compared to control group on day 11. However, in ATCCEC no new resistance was induced. Nevertheless, against 3 antibiotics there was retention of minimal-inhibitory-concentration (MIC) in ATCCEC in different pattern. Further rigorous experiments using more statistically significant models employing different doses and types of mycotoxins in different bacteria would be helpful to definitively establish the role of mycotoxins in ABR.

Keywords: Mycotoxins, deoxyivalenol (DON), Escherichia coli (E. coli), antibiotic resistance (ABR)

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Cite this article

Prathap-KumarK., Narayan S., Shalmali V.S., Balakrishnan-Nair M.N. and Punniyamurthy N. 2024. Impact of mycotoxin deoxynivalenol on antibiotic resistance induction – a proof-of-concept study. J. Vet. Anim. Sci. 55(1):229-232

DOI: https://doi.org/10.51966/jvas.2024.55.1.229-232

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