Journal of Veterinary and Animal Sciences

Volume: 55 Issue: 3

  • Open Access
  • Research Article

Investigation of serum biochemical responses in White Leghorn layer birds following acute avian toxicity screening using indoxacarb

P. U. Aswathy1*, Suresh N Nair1, A. R. Nisha1, Sanis Juliet2, P Anitha3, Asha Rajagopal4 and I. S. Sajitha5

1. Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur680 651, 2Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Pookode, 3Department of Poultry Science, 4Department of Veterinary Parasitology, 5Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala Veterinary and Animal Sciences University, Kerala, India

Year: 2024, Page: 593-597, Doi: https://doi.org/10.51966/jvas.2024.55.3.593-597

Received: March 20, 2024 Accepted: May 17, 2024 Published: Sept. 30, 2024

Abstract

The experiment was undertaken to study the effect of indoxacarb on various biochemical parameters in White Leghorn layer birds for a period of 14 days following a single oral administration. The study follows OECD guideline no. 223. White Leghorn layer birds (n=30) weighing between 1.2 to 1.6 kg were used for the study. Six birds were kept as the control group and approximately 2 ml of blood was collected in EDTA tubes on days 7 and 14 of the experiment. Biochemical parameters such as alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and blood urea nitrogen (BUN) were estimated. The mean values of ALP, AST, ALT and BUN were found significantly higher on days 7 and 14 of the acute toxicity study of indoxacarb in layers as compared to that of the control group.

Keywords: Biochemical, layers, indoxacarb

References

Abdelrasoul, M.A. 2018. Modulation of Abamectin and Indoxacarb -Induced Toxicity on Male Albino Rats by Moringa oleifera. Alex. Sci. Exch. J. 39: 232–243.

Baz, A., 2013. Effect of sub-acute exposure to abamectin ( insecticide ) on liver rats ( Rattus norvegicus ). Ann Toxicol Anal. 25: 63–70.

Choudhary, G.K. and Singh, S.P. 2017. Long term exposure with indoxacarb in WLH cockerels produces reproductive toxicity and its amelioration by rhizome powder of Shati (Hedychium spicatum). Toxicol. Int. 24(11): 269–275.

Dias, J.L. 2006. Environmental fate of indoxacarb. Environmental Monitoring Branch, Sacramento. p1-20. https://www.piat.org.nz/uploads/PIAT_content/pdfs/Indoxacarb%20and%20other%20neurotoxins%20info/Dias%20Environmental%20Fate%20of%20INDOXACARB%202006.pdf (DoA: 25-10-2023)

Foster, J.R., Semino-Beninel, G. and Melching-Kollmuss, S. 2020. The cumulative risk assessment of hepatotoxic chemicals: A hepatic histopathology perspective. Toxicol. Pathol. 48: 397–410.

Goyal, S. and Sandhu, H.S. 2009. Toxic effects of sub-chronic oral exposure of indoxacarb on biochemical parameters in buffalo calves. Toxicol. Int. 16(1): 141-146.

Kumar, S., Madhya, G., Vishwavidyalaya, V., Kumar, A., Garg, U.K., Gupta, S.K., Jatav, G.P. and Rajput, N. 2013.  Effect of indoxacarb induced toxicity on biochemical parameters in broilers (Gallus domesticus). J. Vet. Phar. Tox. 12: 21-23.

Lapied, B., Grolleau, F. and Sattelle, D.B. 2001. Indoxacarb, an oxadiazine insecticide, blocks insect neuronal sodium channels. Br. J. Pharmacol. 132: 587–595.

Mabrouk, Z. EL, Abusrer, S., Shibani, N. and Jaafari, H. El. 2016. The effect of Indoxacarb on blood parameters and liver tissues in Mice Zainab. Libyan J. Vet. Med. Sci. 2: 23–30.

Mccann, S.F., Annis, G.D., Shapiro, R., Piotrowski, D.W., Lahm, G.P., Long, J.K., Lee, K.C., Hughes, M.M., Myers, B.J., Griswold, S.M., Reeves, B.M., March, R.W., Sharpe, P.L., Lowder, P., Barnette, W.E. and Wing, K.D. 2001. The discovery of indoxacarb : oxadiazines as a new class of pyrazoline-type insecticides. Pest Manag. Sci. 57(1): 153–164.

Mudaraddi, T.Y. and Kaliwal, B.B. 2009. Indoxacarb induces hepatic toxicity in Swiss Albino Mice. Res. J. Chem. Env. 1: 40–48.

OECD, 2004. Oecd Guidelines for the Testing of Chemicals. Guidel. Test. Chem. 1–15.

Shit, S.P., Panghal, R.S., Kumar, V. and Rana, R.D. 2008. Acute Toxicity and Gross Behavioural Effects of Indoxacarb in Laboratory Animals. Haryana Vet. 47: 49–50.

Stafford, J.M., Brewer, L.W., Gessaman, J.A., 2003. Avian food selection with application to pesticide risk assessment: Are dead and desiccated insects a desirable food source. Environ. Toxicol. Chem. 22: 1335–1339.

Tsurubuchi, Y. and Kono, Y. 2003. Modulation of sodium channels by the oxadiazine insecticide indoxacarb and its N-decarbomethoxylated metabolite in rat dorsal root ganglion neurons. Pest Manag. Sci. 59: 999–1006.

 

Cite this article

Aswathy, P.U., Suresh, N.N., Nisha, A.R., Sanis, J., Anitha, P., Asha, R. and Sajitha, I.S. 2024. Investigation of serum biochemical responses in White Leghorn layer birds following acute avian toxicity screening using indoxacarb. J. Vet. Anim. Sci. 55 (3):593-597

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