Volume: 56 Issue: 1
Year: 2025, Page: 8-12, Doi: https://doi.org/10.51966/jvas.2025.56.1.8-12
Received: Aug. 11, 2024 Accepted: Dec. 10, 2024 Published: March 31, 2025
Seven female dogs confirmed with CEH-P through history, clinical examination, ultrasonography and blood tests were selected for the study. Animals were treated with mifepristone (5 mg/kg BID PO on days 0, 1, 7 and every seven days until serum progesterone level was below 0.5 ng/mL), cloprostenol (1 μg/kg OD S/C for five consecutive days) and cabergoline (2.5 μg/kg OD PO for 12 days). The animals were evaluated using clinical, haematological, biochemical, B-mode and Doppler ultrasonographic parameters on days 0, 7, 14 and 21. The clinical signs, uterine diameter and haemato-biochemical parameters became normal by day 14 after the onset of treatment. By day 21 the serum progesterone concentrations decreased to below 0.5 ng/mL in all the animals. Animals showed a recovery time of 8.39 ± 1.54 days to regain appetite and 8.36 ± 1.45 days for cessation of vaginal discharge. All haematological and serological parameters returned to normal after medical treatment within 21 days of initiation of treatment, except VPRC, Hb and SDMA. Thus, a combination treatment with antiprogestin, antiprolactin and prostaglandin was found to be safe and effective in medical management of CEH-P with minimal side effects.
Keywords: Cystic endometrial hyperplasia-pyometra, mifepristone, cabergoline, prostaglandin
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© 2025 Suresh et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0
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Suresh A., Simon S., Jayakumar C., Aravind A., Devi S. S. and Chandrasekhar L. 2025. Medical management of canine cystic endometrial hyperplasia-pyometra with mifepristone, cloprostenol and cabergoline.
J. Vet. Anim. Sci. 56 (1):8-12