Journal of Veterinary and Animal Sciences

Volume: 55 Issue: 1

  • Open Access
  • Research Article

N-cadherin expression in canine mammary tumours

A.K. Anseena1, K. Krithiga2, I.S. Sajitha1, S.S. Devi1, K.S. Prasanna1, S. Anoop3 and Nisna Niyas1

1. Department of Veterinary Pathology College of Veterinary and Animal Sciences, Mannuthy, Thrissur – 680651 Kerala Veterinary and Animal Sciences University Wayanad, India

2. BRTC, Thonnakkal, Thiruvananathapuram

3. Department of Veterinary Surgery and Radiology, CVAS, Mannuthy

Year: 2024, Page: 149-155, Doi:

Received: Oct. 12, 2023 Accepted: Nov. 28, 2023 Published: March 31, 2024


Canine mammary tumours (CMT) are the second most common cancer in dogs after skin tumours and are frequently found in older, intact female dogs. Epithelial- Mesenchymal Transition (EMT) is identified as a major driving force in tumour progression and metastasis. The current study was intended to assess the expression of N- cadherin to analyse the invasive and metastatic nature of CMT. A total of 25 CMT cases presented to the University Veterinary Hospitals at Mannuthy and Kokkalai during the period from June 2022 to June 2023 were considered for the present study. By immunohistochemistry (IHC) 48 per cent of cases showed EMT by expressing the cadherin switch. Lymph node metastasis was observed in 4 out of 25 cases during the study period. The expression of N-cadherin could be appreciated in almost all cases which showed lymph node metastasis except for a single CMT sample. The present study confirms the relationship between the expression of N-cadherin in CMT and the presence of regional metastasis and tumour grade. Therefore, the presence of N-cadherin protein in mammary carcinomas could be considered for prognostication.

Keywords: Canine mammary tumour, epithelial mesenchymal transition, N-cadherin, immunohistochemistry


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Cite this article

Anseena, A.K., Krithiga, K., Sajitha, I.S., Devi, S.S., Prasanna, K.S., Anoop, S. and Niyas, N. 2024. N-cadherin expression in canine mammary tumours. J. Vet. Anim. Sci. 55(1):149-155